The acronym PRP stands for “Platelet Rich Plasma”, while PRPHT refers to the use of the technique to counteract baldness (Hair Therapy). This is a therapeutic medical technique that falls within the field of “regenerative medicine”, based on the principle that stem cells, which have been demonstrated to be present in the hair bulb, are equipped with growth factor receptors. This means that the stem cells that give life to hair may be stimulated by implementing signals that induce growth (precisely, growth factors)..
The platelet concentration is rich in growth factors and is therefore used to facilitate hair bulb growth. The PRP is obtained by using a simple blood specimen from the patient, centrifuged in order to isolate the Platelet Rich Plasma from the rest. This preparation is then injected directly into the scalp by using very thin needles, followed by a massage that facilitates their distribution. The patient may then return to his/her normal life after just a few hours, which is why this technique may be considered minimally invasive, if not non-invasive. Hair growth starts to show 2-4 months after the first session and generally reaches a peak after 6 months. Usually some call back sessions are recommended, 3-4 times per year according to the severity of the case.
This clinical protocol is innovative in the field of hair loss treatment, while PRP has already been used for several years in orthopaedic, oral & maxillofacial, and eye surgery and in the treatment of chronic ulcers, in the field of cosmetic surgery for biorevitalization and skin rejuvenation and to stimulate adipose stem cells in autologous lipofilling.
We can therefore exploit the very complicated system of growth factors capable of healing injuries in many organs of the body. Each organ is controlled by specific growth factors, and those of the skin are IGF-1, FGH, and VEGH.
Platelets are bodily cells that circulate in the blood and are active in the blood coagulation process for wounds and bleeding. They are actually among the first cells to trigger the repair and regrowth process of damaged cells; as soon as tissue is damaged, the platelets are “activated” by various natural chemical factors (inflammatory processes, cytokines, macrophages, etc.) and stimulate the cells to "repair themselves".
Either after hair transplants or following the injection of PRP directly into the scalp suffering from hair loss, it is possible to stimulate the bulb with an autologous substance, rich in growth factors. Since PRP is a natural substance taken from the patient, there are no side effects such as possible allergies or intolerances. It is non-toxic and stimulates biorepair and regenerative processes. It stimulates angiogenesis and tissue revascularization. It stimulates the proliferation of mesenchymal cells and, in particular, adult mesenchymal stem cells. It stimulates the formation of collagen. PRP is therefore a source of Growth Factors that derive from the platelet granules of the patient.
HOW IS THE PRP OBTAINED?
PRP is obtained by concentrating the autologous platelets of the patient. A small quantity of blood is drawn (usually 20cc) from the patient, by collecting it in sterile single-use suction tubes with anticoagulant. The tubes are centrifuged for a few minutes, at a specifically scheduled number of turns.
The blood does not come into contact with the environment or with the operator, let alone with the instrument. At the end of the centrifugation, the samples are analysed in two phases: the lower sediment part features red and white blood cells. The upper part features plasma and platelets with growth factors. By using a special pipette, the PRP is suctioned and a chemical activator is added to degranulate the platelets, facilitating the outflow of growth factors. The prepared PRP may then be injected into the scalp by using a sterile syringe. The operations must be consecutive, given that the platelets have a short lifespan. The blood must be drawn from the individual who is to be treated. The preparation, which lasts around 45 minutes, is carried out by specialized clinical personnel or hematologists. Thus, no risks are present in this treatment. The centrifugation does not alter the blood cells and is used solely to separate them. If the entire procedure carried out by qualified personnel is conducted in a designated environment, there is no risk of contamination.
As far as results in hair loss treatments are concerned, the growth factors stimulate the bulb cells (of the dermal papilla, matrix and melanocytes) to keep the anagen phase active, produce the hair shaft, reduce inflammatory processes in the skin and reduce cellular death. Moreover, the extremely high concentration of natural growth factors is able to stimulate stem cells in the remaining bulbs to once again generate a hair bulb. Thus, in the case of pattern hair loss, this procedure can lead to the regrowth of a number of hairs (obviously not quantifiable beforehand), especially in the early stages of the illness (in particular from stages I to IV of the Hamilton scale and in stages I to II of the Ludwig scale).
According to scientific literature, significant growth is seen in 60-70% of cases. On average, 2-4 sessions are performed over the course of 3 months; in alopecia areata (spot baldness), this may well be the most important treatment technique in terms of hair regrowth percentages in active patches. In scarring hair loss, it may have a significant effect on inflammation control and for decreasing the progression of active hair bulb death, especially in early forms. If residual hair follicle stem cells exist in the dermis, they may also be stimulated.
PRP therapy can be considered one of the most advanced and effective therapy techniques in the trichological field. Success depends, however, on the type of illness, on various concurrent situations and on the presence or lack of stem cells that may be activated. The most advanced theories now tend to use a treatment with PRP before, during or after the micro-autotransplant operation, in order to obtain:
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ADVIHAIR S.R.L., VAT N° 11495171008, with its offices at Via Benini n. 11 - 40069 Zola Predosa (Bologna, Italy), (hereinafter referred to as the, "Data Controller"), in its capacity as Data Controller, hereby informs you, in accordance with Art. 13 of EU Regulation n. 679/2016 (hereinafter referred to as, "GDPR") that your personal data (provided at the moment of subscription, by means of which business relationships deriving from the existing contract are established) shall be processed in compliance with the methods and for the purposes specified below. In accordance with the provisions of both the GDPR, Italian Legislative Decree n. 196/2003 and any subsequent amendments (hereinafter referred to as the "Privacy Code"), the processing operations carried out by the Data Controller, shall be based on principles of correctness, lawfulness and transparency and they shall be carried with the aim of complying with the principles of relevance, completeness, non-excessiveness while also safeguarding confidentiality.
The scope of data processing
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The Data Controller shall process the personal data for the necessary time so as to fulfil the aforementioned purposes and, in any case, for no longer than 10 years after the business relationship has ended, for the primary purposes and for no longer than 2 years after the need for data processing for Marketing Purposes has ended. The images shall be kept indefinitely and stored in the databases so as to have a historical memory of the events. Anyhow, a periodic verification is carried out relating to the obsolescence of the data stored in relation to the purposes for which they had been collected.Categories of Individuals to whom the data may be communicated:
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The Data Controller of the personal data you provided is: ADVIHAIR S.R.L., VAT N° 11495171008, with its offices at Via Benini n. 11 - 40069 Zola Predosa (Bologna, Italy) in the person of its Legal Representative. Articles from 15 to 22 of the GDPR are available by clicking on this link: http://eur-lex.europa.eu/legal-content/IT/TXT/HTML/?uri=CELEX:32016R0679&from=IT